Table 1.
Liver transcriptome analysis of Zmpste24−/− reveals somatotroph axis transcriptional alterations
| Gene name | Gene symbol | Zmpste24−/− vs. WT fold change |
| Signal transducer and activator of transcription 5B | Stat5b | 7.55 |
| IGF-binding protein 1 | Igfbp1 | 6.37 |
| Suppressor of cytokine signaling 3 | Socs3 | 4.61 |
| IGF-binding protein 3 | Igfbp3 | 3.17 |
| Suppressor of cytokine signaling 2 | Socs2 | 2.20 |
| Protein tyrosine phosphatase, nonreceptor type substrate 1 | Ptpns1 | 2.09 |
| Estrogen-related receptor, alpha | Esrra | 1.84 |
| Janus kinase 2 | Jak2 | 1.28 |
| Suppressor of cytokine signaling 1 | Socs1 | −1.28 |
| Suppressor of cytokine signaling 5 | Socs5 | −1.41 |
| Fibroblast growth factor receptor 4 | Fgfr4 | −1.52 |
| Fibroblast growth factor 4 | Fgf4 | −1.67 |
| Cytokine-inducible SH2-containing protein | Cish | −1.71 |
| Insulin-like growth factor 1 | IGF-1 | −1.76 |
| Growth hormone receptor | Ghr | −1.82 |
| Insulin-like growth factor binding protein 5 | Igfbp5 | −1.98 |
| Deiodinase, iodothyronine, type I | Dio1 | −4.46 |
| IGF-binding protein, acid labile subunit | Igfals | −7.24 |