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. 2010 Aug 30;107(37):16342–16347. doi: 10.1073/pnas.1007583107

Fig. 3.

Fig. 3.

Social influences on serum IL-6 and corticosterone levels. CA/CPR animals displayed elevated levels of circulating IL-6 at (A) 24 and (B) 72 h postsurgery with socially isolated animals displaying significantly higher levels than their paired counterparts. (C) IL-6 levels returned to control levels in the CA/CPR groups by 7 d following surgery. (D) Both the socially isolated and paired CA/CPR groups displayed elevated serum corticosterone concentrations at 24 h relative to controls. Corticosterone concentrations had returned to control levels by 72 h postsurgery among the paired CA/CPR group (E and F), but remained significantly elevated at both the 72-h (E) and 7-d (F) time points among the socially isolated CA/CPR group. The control group was comprised of sham-operated mice and mice that underwent hypothermic CA/CPR and as a result did not sustain neuroinflammation or neuronal damage. Data are presented as mean ± SEM. *, significantly different from isolated CA/CPR animals. (P < 0.05). †Significantly different from controls (P < 0.05).