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. 2010 Aug 30;107(37):16342–16347. doi: 10.1073/pnas.1007583107

Fig. 5.

Fig. 5.

Social influences on behavioral outcome. (A) The CA/CPR procedure resulted in significantly increased locomotor activity independent of housing conditions. (B) CA/CPR also led to increased levels of anxiety-like behavior regardless of housing conditions, as measured by decreased central tendency in the open field. (C) CA/CPR engendered increased levels of floating in the forced swim task, which is interpreted as increased depressive-like behavior. Social isolation exacerbated this effect with isolated CA/CPR mice displaying increased depressive-like behavior as compared with pair-housed CA/CPR mice and controls. The control group was comprised of sham-operated mice and mice that underwent hypothermic CA/CPR and as a result did not sustain neuroinflammation or neuronal damage. Data are presented as mean ± SEM. *Significantly different from isolated CA/CPR animals. (P < 0.05). †Significantly different from controls (P < 0.05).