Table 3.

Rai classification and Binet staging systems for CLL

System	Clinical features	Median survival, y
Rai stage (simplified 3-stage)
0 (low risk)	Lymphocytosis in blood and marrow only	> 10
I and II (intermediate risk)	Lymphadenopathy, splenomegaly +/− hepatomegaly	7
III and IV (high risk)	Anemia, thrombocytopenia	0.75-4
Binet group
A	Fewer than 3 areas of lymphadenopathy; no anemia or thrombocytopenia	12
B	More than 3 involved node areas; no anemia or thrombocytopenia	7
C	Hemoglobin < 100 g/L platelets < 100 × 10 g/L	2-4