Table 5.

Criteria for response to therapy in CLL

Response level/criteria
CR
Absence of clonal lymphocytosis
Absence of significant lymphadenopathy
No hepatosplenomegaly by physical examination
Absence of constitutional symptoms
Neutrophils ≥ 1500/μL
Platelets > 100 000/μL
Hemoglobin > 11.0 g/dL untransfused
BM free of clonal lymphocytes (in clinical trials only)
CRi
As for CR, but with persistent anemia, thrombocytopenia, or neutropenia
PR
Decrease of ≥ 50% in the number of blood lymphocytes
Decrease of ≥ 50% in lymph node size in the sum products of up to 6 lymph nodes, no increase in any lymph node, and no new enlarged lymph nodes
Decrease of ≥ 50% in the size of hepatosplenomegaly
One of the following:
Neutrophils ≥ 1500/μL or > 50% improvement from baseline
Platelets > 100 000/μL or > 50% improvement from baseline
Hemoglobin > 11.0 g/dL or > 50% improvement from baseline

CR indicates complete response; CRi, CR with incomplete marrow recovery; and PR, partial response.