Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2011 Sep 23.

Published in final edited form as: J Med Chem. 2010 Sep 23;53(18):6747–6757. doi: 10.1021/jm100592u

Table 2.

Competitive Binding Study for Compounds 1, 2, and 5a.^a

		Inhibitor Concentration (mM)
Compound	Inhibitor	0.0	0.5	1.0	2.0
			K_A (mM⁻¹)

1	homocysteine	5.0 ± 1.5	2.0 ± 0.12	1.5 ± 0.2	0.87 ± 0.05
2	homocysteine	64 ± 16	17 ± 2.2	6.1 ± 0.54	3.6 ± 0.23
5a	homocysteine	22 ± 1.4	11 ± 3.4	6.6 ± 2.7	3.4 ± 0.84
5a	5b	22 ± 1.4	6.2 ± 1.2	3.0 ± 0.91	~ 0

^a

Measured at 37°C.