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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Semin Immunol. 2010 Oct;22(5):294–302. doi: 10.1016/j.smim.2010.04.013

Figure 1.

Figure 1

Schematic representation of the Erk-Elk (green) and calcineurin-NFAT (blue) sensor modules in thymocytes. Plain arrows indicate activation, dashed arrows nuclear import. The membrane-proximal signaling event that lead to PLCγ 1 activation are not depicted. Active PLCγ 1 releases inositol triphosphate and diacyl glycerol, which cause calcium release from intra-cellular stores (and the ensuing opening of plasma membrane CRAC channels) and activation of Ras via the exchange factor RasGRP1 [157,158], respectively.