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. 2010 Sep 6;10:11. doi: 10.1186/1471-2210-10-11

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Copyright ©2010 Wang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gliosis by MCAO in rats (n = 8 in each group of different treatments). *The number of GFAP-positive cells (B) 4 days after MCAO injury was significantly (P < 0.05) increased for MCAO-injured animals treated with an i.v. dose of normal saline (1 ml/kg) compared with MCAO sham controls. ^†The increased number of GFAP-positive cells 4 days after MCAO injury was significantly decreased for MCAO-injured animals treated with an i.v. dose of agmatine (100 mg/kg) compared with vehicle controls. The photomicrograph (A) illustrates a typical example for a sham-operated control, a vehicle-treated MCAO rat, and an agmatine-treated MCAO rat.