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. Author manuscript; available in PMC: 2011 Oct 8.
Published in final edited form as: Brain Res. 2010 Aug 4;1355:70–85. doi: 10.1016/j.brainres.2010.07.094

Figure 12. Summary schematic of histological observations and hypothetical model of hindbrain regulation of thermogenesis.

Figure 12

Our previous physiological studies showed a synergistic relationship between leptin and TRH on hindbrain thermogenic circuits. Our current IHC observations on the localization of receptors for TRHR1 and LepRb offer several means by which leptin and TRH might interact to augment thermogenesis. The co-localization of these two receptors on individual neurons in the NST affords the possibility that signal transduction pathways of these two ligands might interact directly, as suggested in our previous studies. Further, leptin action on glutamatergic fibers and TRH action on serotonin fibers could, together, powerfully modulate synaptic inputs to circuit elements important to regulating thermogenesis.