. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: J Med Genet. 2009 Jul 2;46(12):856–861. doi: 10.1136/jmg.2009.067892

Table 1.

Segregation of enlargement of the vestibular aqueduct (EVA) among siblings ascertained at the National Institutes of Health

Number of SLC26A4 mutations in proband	Number of siblings		Segregation ratio^* (95% CI)
Number of SLC26A4 mutations in proband	Affected	Unaffected	Segregation ratio^* (95% CI)
0	4	27	0.13 (0.052 to 0.29)
1	4	2	0.67 (0.29 to 0.90)
2	5	6	0.45 (0.21 to 0.72)
Total	13	35	0.27 (0.17 to 0.41)

CI, confidence interval.

The M1 ratio of 0.67 was significantly higher (p=0.011) than the M0 ratio of 0.13, but did not differ significantly (p=0.62) from the M2 ratio of 0.45. The segregation ratio in the M0 group was significantly lower (p=0.037) than that in the M2 group.