. Author manuscript; available in PMC: 2010 Dec 1.

Published in final edited form as: J Med Genet. 2009 Jul 2;46(12):856–861. doi: 10.1136/jmg.2009.067892

Table 2.

Segregation of enlargement of the vestibular aqueduct (EVA)^* among the entire cohort of 83 siblings

Number of SLC26A4 mutations in proband	Number of siblings		Segregation ratio^† (95% CI)
Number of SLC26A4 mutations in proband	Affected	Unaffected	Segregation ratio^† (95% CI)
0	4	34	0.11 (0.043 to 0.24)
1	4	4	0.50 (0.21 to 0.79)
2	10	27	0.27 (0.15 to 0.43)
Total	18	65	0.22 (0.14 to 0.32)

CI, confidence interval.

Includes EVA inferred from outside evaluations and family history interviews.

^†

The M1 ratio of 0.50 was significantly higher (p=0.02) than the M0 ratio of 0.11, but did not differ significantly (p=0.23) from the M2 ratio of 0.27.