Table 2.
Association of TNF, MBL and VDR Polymorphism with Leprosy & Leprosy Type with Dominant and Recessive Models
| SNP | Outcome | Recessive | Dominant | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AA + Aa | aa | OR | χ 2 | 1P | AA | Aa + aa | OR | χ 2 | 1P | ||
| n (%) | n (%) | n (%) | n (%) | ||||||||
| TNF_G−308A | Control | 92 (97.9) | 2 (2.1) | 79 (84.0) | 15 (16.0) | ||||||
| Leprosy | 817 (99.6) | 3 (0.4) | 0.17 (0.02–2.05) | NA* | 0.085** | 743 (90.6) | 77 (9.4) | 0.55 (0.29–1.07) | 4.02 | 0.045 | |
| MBL_C154T | Control | 99 (100.0) | 0 (0.0) | 91 (91.9) | 8 (8.1) | ||||||
| Leprosy | 889 (99.9) | 1 (0.1) | NA | NA* | 1.000** | 831 (93.4) | 59 (6.6) | 0.81 (0.37–2.02) | 0.30 | 0.586 | |
| MBL_G161A | Control | 97 (98.0) | 2 (2.0) | 82 (82.8) | 17 (17.2) | ||||||
| Leprosy | 864 (97.5) | 22 (2.5) | 1.23 (0.30–10.99) | NA* | 1.000** | 676 (76.3) | 210 (23.7) | 1.50 (0.86–2.76) | 2.14 | 0.143 | |
| MBL_G170A | Control | 100 (100.0) | 0 (0.0) | 97 (97.0) | 3 (3.0) | ||||||
| Leprosy | 886 (100.0) | 0 (0.0) | NA | NA* | 0.000** | 855 (96.5) | 31 (3.5) | 1.17 (0.36–6.10) | 0.07 | 1.000 | |
| VDR_ BsmI G→A | Control | 90 (90.9) | 9 (9.1) | 54 (54.5) | 45 (45.5) | ||||||
| Leprosy | 791 (90.9) | 79 (9.1) | 1.00 (0.48–2.34) | 0.00 | 0.997 | 465 (53.4) | 405 (46.6) | 1.05 (0.67–1.63) | 0.04 | 0.836 | |
| VDR_ FokI C→T | Control | 94 (93.1) | 7 (6.9) | 45 (44.6) | 56 (55.4) | ||||||
| Leprosy | 797 (89.0) | 99 (11.0) | 1.67 (0.75–4.38) | 1.62 | 0.203 | 423 (47.2) | 473 (52.8) | 0.90 (0.58–1.39) | 0.26 | 0.612 | |
| VDR_ TaqI T→C | Control | 89 (91.8) | 8 (8.2) | 58 (59.8) | 39 (40.2) | ||||||
| Leprosy | 827 (94.8) | 45 (5.2) | 0.61 (0.27–1.54) | 1.61 | 0.205 | 548 (62.8) | 324 (37.2) | 0.88 (0.56–1.39) | 0.35 | 0.556 | |
| TNF_G−308A | Tuberculoid | 314 (99.4) | 2 (0.6) | 285 (90.2) | 31 (9.8) | ||||||
| Lepromatous | 495 (99.8) | 1 (0.2) | 0.32 (0.01–6.12) | 0.98 | 0.564 | 450 (90.7) | 46 (9.3) | 0.94 (0.57–1.57) | 0.06 | 0.799 | |
| MBL_C154T | Tuberculoid | 326 (100.0) | 0 (0.0) | 311 (95.4) | 15 (4.6) | ||||||
| Lepromatous | 555 (99.8) | 1 (0.2) | NA | NA* | 513 (92.3) | 43 (7.7) | 1.74 (0.93–3.42) | 3.28 | 0.070 | ||
| MBL_G161A | Tuberculoid | 313 (95.7) | 14 (4.3) | 248 (75.8) | 79 (24.2) | ||||||
| Lepromatous | 543 (98.5) | 8 (1.5) | 0.33 (0.12–0.85) | 6.73 | 0.010 | 422 (76.6) | 129 (23.4) | 0.96 (0.69–1.34) | 0.06 | 0.801 | |
| MBL_G170A | Tuberculoid | 327 (100.0) | 0 (0.0) | 312 (95.4) | 15 (4.6) | ||||||
| Lepromatous | 551 (100.0) | 0 (0.0) | NA | NA* | 535 (97.1) | 16 (2.9) | 0.62 (0.28–1.37) | 1.71 | 0.191 | ||
| VDR_ BsmI G→A | Tuberculoid | 291 (90.7) | 30 (9.3) | 168 (52.3) | 153 (47.7) | ||||||
| Lepromatous | 495 (91.5) | 46 (8.5) | 0.90 (0.54–1.51) | 0.18 | 0.673 | 292 (54.0) | 249 (46.0) | 0.94 (0.70–1.25) | 0.22 | 0.641 | |
| VDR_ FokI C→T | Tuberculoid | 293 (89.3) | 35 (10.7) | 162 (49.4) | 166 (50.6) | ||||||
| Lepromatous | 496 (88.6) | 64 (11.4) | 1.08 (0.69–1.72) | 0.12 | 0.729 | 256 (45.7) | 304 (54.3) | 1.16 (0.87–1.54) | 1.12 | 0.290 | |
| VDR_ TaqI T→C | Tuberculoid | 307 (95.3) | 15 (4.7) | 199 (61.8) | 123 (38.2) | ||||||
| Lepromatous | 514 (94.8) | 28 (5.2) | 1.11 (0.56–2.28) | 0.11 | 0.740 | 344 (63.5) | 198 (36.5) | 0.93 (0.69–1.25) | 0.24 | 0.624 |
1
P value comparison by Chi-square (χ2) unless otherwise indicated. P values <0.05 are in bold.
*
Fisher exact test computes p value directly and therefore is not associated with Chi square values.
**
Corrected p value by Fisher's exact due to small cell frequencies
N/A, not available.