Table 3.
Association of TNF, MBL and VDR Polymorphisms with Leprosy Reactions
| SNPs variable | Outcome | Allele frequency (%) | OR (95% CI) | χ 2 | 1P | Genotype frequency (%) | χ 2 | 2P | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A | a | AA | Aa | aa | |||||||
| TNF_G−308A | No RR | 727 (94.4) | 43 (5.6) | 344 (89.4) | 39 (10.1) | 2 (0.5) | |||||
| RR | 374 (95.9) | 16 (4.1) | 0.72 (0.38–1.33) | 1.18 | 0.278 | 180 (92.3) | 14 (7.2) | 1 (0.5) | 1.36 | 0.549 | |
| MBL_C154T | No RR | 797 (96.5) | 29 (3.5) | 384 (93.0) | 29 (7.0) | 0 (0.0) | |||||
| RR | 422 (97.7) | 10 (2.3) | 0.65 (0.28–1.39) | 1.35 | 0.245 | 206 (95.4) | 10 (4.6) | 0 (0.0) | 1.40 | 0.297 | |
| MBLG161A | No RR | 703 (85.7) | 117 (14.3) | 306 (74.6) | 91 (22.2) | 13 (3.2) | |||||
| RR | 373 (86.3) | 59 (13.7) | 0.95 (0.67–1.35) | 0.09 | 0.768 | 163 (75.5) | 47 (21.8) | 6 (2.8) | 0.10 | 0.985 | |
| MBL_G170A | No RR | 811 (97.9) | 17 (2.1) | 397 (95.9) | 17 (4.1) | 0 (0.0) | |||||
| RR | 418 (98.1) | 8 (1.9) | 0.91 (0.34–2.26) | 0.04 | 0.833 | 205 (96.2) | 8 (3.8) | 0 (0.0) | 0.05 | 1.000 | |
| VDR_ BsmI G→A | No RR | 587 (72.5) | 223 (27.5) | 216 (53.3) | 155 (38.3) | 34 (8.4) | |||||
| RR | 310 (74.5) | 106 (25.5) | 0.90 (0.68–1.19) | 0.59 | 0.443 | 118 (56.7) | 74 (35.6) | 16 (7.7) | 0.64 | 0.731 | |
| VDR_ FokI C→T | No RR | 581 (69.8) | 251 (30.2) | 209 (50.2) | 163 (39.2) | 44 (10.6) | |||||
| RR | 276 (63.9) | 156 (36.1) | 1.31 (1.01–1.68) | 4.60 | 0.032 | 91 (42.1) | 94 (43.5) | 31 (14.4) | 4.33 | 0.111 | |
| VDR_ TaqI T→C | No RR | 645 (79.6) | 165 (20.4) | 260 (64.2) | 125 (30.9) | 20 (4.9) | |||||
| RR | 332 (78.3) | 92 (21.7) | 1.08 (0.80–1.46) | 0.30 | 0.585 | 128 (60.4) | 76 (35.8) | 8 (3.8) | 1.80 | 0.432 | |
| TNF_G−308A | No ENL | 677 (94.8) | 37 (5.2) | 321 (89.9) | 35 (9.8) | 1 (0.3) | |||||
| ENL | 218 (96.5) | 8 (3.5) | 0.67 (0.27–1.49) | 1.02 | 0.314 | 105 (92.9) | 8 (7.1) | 0 (0.0) | NA* | 0.587** | |
| MBL_C154T | No ENL | 790 (96.1) | 32 (3.9) | 380 (92.5) | 30 (7.3) | 1 (0.2) | |||||
| ENL | 229 (96.2) | 9 (3.8) | 0.97 (0.40–2.12) | 0.01 | 0.937 | 110 (92.4) | 9 (7.6) | 0 (0.0) | NA* | 1.000** | |
| MBL_G161A | No ENL | 710 (88.1) | 96 (11.9) | 313 (77.7) | 84 (20.8) | 6 (1.5) | |||||
| ENL | 205 (85.4) | 35 (14.6) | 1.26 (0.81–1.94) | 1.21 | 0.272 | 86 (71.7) | 33 (27.5) | 1 (0.8) | NA* | 0.266** | |
| MBL_G170A | No ENL | 802 (98.8) | 10 (1.2) | 396 (97.5) | 10 (2.5) | 0 (0.0) | |||||
| ENL | 234 (98.3) | 4 (1.7) | 1.37 (0.31–4.80) | 0.28 | 0.595 | 115 (96.6) | 4 (3.4) | 0 (0.0) | NA* | 0.532** | |
| VDR_ BsmI G→A | No ENL | 574 (72.1) | 222 (27.9) | 212 (53.3) | 150 (37.7) | 36 (9.0) | |||||
| ENL | 174 (74.4) | 60 (25.6) | 0.89 (0.63–1.25) | 0.46 | 0.498 | 66 (56.4) | 42 (35.9) | 9 (7.7) | 0.43 | 0.831 | |
| VDR_ FokI C→T | No ENL | 550 (66.4) | 278 (33.6) | 187 (45.2) | 176 (42.5) | 51 (12.3) | |||||
| ENL | 171 (71.3) | 69 (28.8) | 0.80 (0.57–1.10) | 1.97 | 0.160 | 59 (49.2) | 53 (44.2) | 8 (6.7) | 3.07 | 0.223 | |
| VDR_ TaqI T→C | No ENL | 619 (78.0) | 175 (22.0) | 244 (61.5) | 131 (33.0) | 22 (5.5) | |||||
| ENL | 193 (81.8) | 43 (18.2) | 0.79 (0.53–1.15) | 1.59 | 0.207 | 80 (67.8) | 33 (28.0) | 5 (4.2) | 1.60 | 0.481 | |
P value for comparison of allele frequencies by Chi-square (χ2) unless otherwise indicated. “A” denotes common allele and “a” denotes minor allele. P values <0.05 are in bold. The analysis of reversal reaction (RR) compares those with and without RR within the group of leprosy cases with BB, BT or BL. The analysis of erythema nodosum leprosum (ENL) compares those with and without ENL within the group of leprosy cases with BL or LL.
P value for comparison of genotype frequencies by Chi-square (χ2) unless otherwise indicated.
Fisher exact test computes p value directly and therefore is not associated with Chi square values.
Corrected p value by Fisher's exact due to small cell frequencies.
NA, not available.