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. Author manuscript; available in PMC: 2011 Sep 17.
Published in final edited form as: Circ Res. 2010 Jul 22;107(6):737–746. doi: 10.1161/CIRCRESAHA.109.215715

Figure 2. Oxidized phospholipids induce a unique gene expression pattern.

Figure 2

Bone marrow-derived macrophages were stimulated with 10U/ml IFNγ plus 1μg/ml LPS (M1), 10ng/ml IL-4 (M2), 50μg/ml OxPAPC (Mox), or medium only (M0), for 3 hours. (A) Affimetrix gene array analysis and subsequent heat map generation identify unique clustering patterns for each macrophage phenotype. (B) Differentially upregulated genes were identified by selecting for the top 5% of total genes exhibiting greater than 1.5-fold induction. A Venn-diagram of overlapping genes is shown, which represents intersections of probe set IDs. Numbers represent total probe sets including duplicate gene titles as present on the array (refer to supplemental tables).