Table 2.
Association of Polymorphisms of ERβ (CA)n repeat by Overall Survival and Gender.
| Univariate analysis | |||
|---|---|---|---|
| All patients |
|||
| ER β (CA)n repeat | N (%) | Median survival (95% CI), mo |
RR (95% CI) |
| Any (CA)n <22 | 224 (71%) | 14.0 (11.9–16.2) | 1 (Reference) |
| Both (CA)n ≥ 22 | 91 (29%) | 13.4 (10.3–15.6) | 1.10 (0.85, 1.43) |
| Log-rank P | 0.48 | ||
| Female | Male | |||||
|---|---|---|---|---|---|---|
| EER β (CA)n repeat |
Median survival (95% CI), mo |
RR (95% CI) | N (%) | Median survival (95% CI), mo |
RR (95% CI) | |
| Any (CA)n <22 | 101(72%) | 14.1(12.0–17.9) | 1(Reference) | 123(70%) | 13.6(10.1–16.8) | 1 (Reference) |
| Both (CA)n ≥ 22 | 39(28%) | 18.4(14.7–26.6) | 0.69(0.45, 1.06) | 52(30%) | 10.3(7.9–13.1) | 1.51 (1.07, 2.12) |
| Log-rank P | 0.083 | 0.014 | ||||
|
P for interaction of Female vs Male |
0.003 | |||||
| Multivariate analysis | |||
|---|---|---|---|
| All patients |
Female |
Male |
|
| ER β (CA)n repeat | RR (95% CI)* | RR (95% CI)* | RR (95% CI)* |
| Any (CA)n <22 | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Both (CA)n ≥ 22 | 0.99 (0.75, 1.30) | 0.62 (0.39, 1.00) | 1.34 (0.94, 1.90) |
| Adjusted P* | 0.93 | 0.05 | 0.11 |
| P for interaction† | 0.005 | ||
*
Based on Cox proportional hazards model; adjusted by age and previous treatments and stratified by race; P values were based on Wald test in the multivariate model.
†
Based on the likelihood ratio test; adjusted by age and previous treatments and stratified by race.