TABLE 2.

Comparison of plasma anti-inflammatory cytokine concentrations (ng/ml) in AKITA and Wild Type (WT) mice 24 hours prior to death^*

CYTOKINE (ng/ml)	WT-Survived	WT-Died	AKITA
Interleukin (IL)-1ra	3.8 ± 1.0	13.8 ± 2.4†	1.5 ± 0.4
IL-4	0.5 ± 0.08	1.1 ± 0.2†	0.2 ± 0.05
IL-10	1.3 ± 0.3	17.0 ± 7.6†	1.4 ± 0.5
IL-13	2.1 ± 0.4	6.0 ± 1.1†	0.7 ± 0.2
TNF-srI	1.6 ± 0.3	7.3 ± 1.5†	2.7 ± 1.0
TNF-srII	0.4 ± 0.1	1.4 ± 0.2†	0.4 ± 0.1

^*The pooled pre-lethal cytokine values were collected from mice dying between days 1–5 post-CLP (acute sepsis). Dying mice were matched with the WT-survived animals (n=18) of the same post-CLP day as the moribund mouse.

^†p<0.01 WT-Died versus WT-Survived and AKITA. Data are mean ± SEM.