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Peak change from baseline means (±SEM) for visual analog item Drug Effect, observer rated Agonist, and pupil diameter for doses of hydromorphone (2, 4 mg), buprenorphine (4, 8, and 16 mg), and buprenorphine/naloxone (4/2, 8/4, and 16/8 mg). * p≤0.05 versus placebo.
