Fig. 2.

Trial detection and filtering for a portion of recorded motor tasks including continuous movement, velocity profiles, and filtering of horizontal and vertical components. A: An overlay of computer mouse x and y positions with the starting position and reach targets. Patients were instructed to move a computer mouse from the starting position (bottom center) to either the upper left or upper right corners of a computerized tablet, then return to the starting position. The target of each sequence was relayed verbally as a cue to begin movement. Movement sequences (outward reach and return) typically lasted 2–3 seconds with a brief pause at the target; however, only data recorded during outward reaching movement were used for analysis. Trials were marked by evaluating times at which velocity crossed a threshold. B: Overlaid velocity profiles of trials in the up-left direction. C: Filtering of the vertical component of movement for each trial in the up-left direction. D: Filtering of the horizontal component of movement for each trial in the up-left direction. In both the vertical and horizontal cases, the thick dark lines indicate a single SD away from the average path. To be retained for further analysis, a trial must be ≥ 80% within the boundaries in both the horizontal and vertical components of movement. Retained trials are shown in green; discarded trials are shown in dashed red. Overall, 55% of trials in the patient in Case 1 and 56% of trials in Case 2 were retained for analysis.