Figure 2.

AR NPs inhibit HIV-1 replication in MDMs in vitro. Virus replication was measured by the level of capsid protein (p24) released into the medium at the days indicated. Cells were treated as indicated for 4 h at 1 day post-infection. Control represents HIV-1-infected MDMs. (a) Data from an experiment in which free drugs were given at 0.01 mg/mL and AR NP was given at 0.005 mg/mL. (b) Data from an experiment in which MDMs were treated with 0.1 mg/mL free drugs or 0.05 mg/mL AR NPs. Error bars represent SEM. Data are representative of three independent experiments. **A significant difference between blank NPs or control MDMs and free AR drugs or AR NPs (P < 0.01). EFV, efavirenz; LPV/r, lopinavir/ritonavir.