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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: J Thromb Haemost. 2010 May 12;8(8):1847–1854. doi: 10.1111/j.1538-7836.2010.03907.x

Figure 6.

Figure 6

Pro- and anti-migratory effects of PAI-1 and VN on VSMC. VN binds collagen and stimulates (+) VSMC migration by interacting with αVβ3 and uPA receptor (uPAR). PAI-1 stimulates VSMC migration by binding to a plasminogen activator (PA), which exposes an LRP binding site on PAI-1, leading to engagement of the complex with LRP, a motogenic receptor. Binding of PAI-1 to VN yields a complex that is not motogenic, providing a mechanism for each factor to inhibit the pro-migratory effect of the other.