Table 1.
Oral Carcinogenesis after 4-NQO Treatment, Vitamin A Sufficient Diet
| Incidence a | Number of Tumors |
Size of Tumors (mm)b |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | ≥3 | <1 | ≥1 | ≥2 | ≥3 | ||
| Wt (n=19) | 73.7% | 5 | 5 | 5 | 4 | 4 | 3 | 2 | 4 |
| LRAT−/− (n=20) | 80.8% | 4 | 8 | 4 | 4 | 3 | 4 | 4 | 5 |
a
No statistically different incidence in oral tumors was detected between the Wt mice and LRAT−/− mice (p=0.716, Fisher’s exact test). The incidence of tumors was determined by gross examination of the tongues. The samples with visible tumors, regardless of the number and size of the tumors, were counted as one positive case.
b
If a sample contained more than one tumor, the size of tumor is indicated by the largest mass on the tongue