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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Surgery. 2011 Jan;149(1):114–125. doi: 10.1016/j.surg.2010.04.001

Figure 8.

Figure 8

Suggested model of the effects of intestinal interstitial edema development on intestinal contractile activity. Edema alters both the mechanical properties of the tissue and the cytoskeletal properties in the mucosal and muscle layers of the small intestine. These changes may induce increased NHE activity in the mucosa that eventually lead to sequential increases in intestinal smooth muscle STAT3 phosphorylation, decreased myosin light chain phosphorylation and, finally, decreased intestinal contractile activity.