. Author manuscript; available in PMC: 2011 Mar 15.

Published in final edited form as: Cancer Res. 2010 Sep 15;70(18):7017–7026. doi: 10.1158/0008-5472.CAN-10-1202

Table 2.

Test cohort A (1995-2000): DNA damage signalling proteins’ median percentage score, intensity and semi-quantitative score (SQS) with ranges; median expression scores with ranges in patients who died of bladder cancer or were still alive at 3 years (Ki67 was scored as a percentage of positive nuclei alone); associations of protein expression by quartile with CSS.

Protein	Percentage positive nuclei: Median (range)	Intensity: Mode (range)	Semiquantitative score: Median (range)	Died of bladder cancer at 3 years: Number Median score (range)	Alive at 3 years: Number Median score (range)	Quartile	No of cases	3yr cause-specific survival	p-value
MRE11	91.2 (17.1-98.6)	2 (0-3)	182 (28-296)	31 167 (48-294)	45 186 (28-296)	≤ 25^th	21	43.1	p=0.069
						25-50^th	23	65.5
						50-75^th	21	71.4
						≥ 75^th	21	71.4
NBS1	62.6 (6.0-93.2)	2 (0-3)	125 (6-280)	30 122 (6-239)	45 110 (11-280)	≤ 25^th	21	57.1	p=0.76
						25-50^th	22	68.2
						50-75^th	22	67.2
						≤ 75^th	21	61.8
RAD50	95.3 (24.3-99.9)	2 (0-3)	193 (24-299)	31 192 (84-297)	45 191 (24-299)	≤ 25th	21	66.3	p=0.94
						25-50^th	23	60.9
						50-75^th	22	61.9
						≥ 75^th	21	62.0
ATM	85.2 (24.0-97.3)	2 (0-3)	174 (6-292)	30 172 (48-285)	45 170 (48-292)	≤ 25^th	22	72.7	p=0.83
						25-50^th	22	54.5
						50-75^th	21	70.8
						≥ 75^th	21	56.7
H2AX	7.4 (1-60.0)	1 (0-3)	10 (1-149)	29 16 (1-120)	45 8 (1-149)	≤ 25^th	20	79.2	p=0.49
						25-50^th	21	65.5
						50-75^th	23	63.6
						≥ 75^th	21	50.8
Ki67	27.8 (2.0-74.0)			30 30 (2-74)	45 26 (5-52)	≤ 25^th	21	63.3	p=0.56
						25-50^th	23	60.1
						50-75^th	21	74.8
						≥ 75^th	21	51.9