Table 3.
Multivariate cause-specific analyses using Cox proportional hazards regression analysis to determine hazard ratios (HR) and p-values in the 1995-2000 and 2002-2005 radiotherapy datasets (Cohorts A and B) and the 1995-2005 cystectomy dataset. Numbers in bold represent significance at the 5% level.
| Cohort A | Cohort B | Combined A + B | Cystectomy | |||||
|---|---|---|---|---|---|---|---|---|
| Category (87 cohort A, 93 cohort B, 88 cystectomy) |
Univariate model HR (95% CI) (p-value) |
Multivariate model HR (95% CI) (p-value |
Univariate model HR (95% CI) (p-value) |
Multivariate model HR (95% CI) (p-value) |
Univariate model HR (95% CI) (p-value |
Multivariate model HR (95% CI) (p-value) |
Univariate model HR (95% CI) (p-value) |
Multivariate model HR (95% CI) (p-value) |
| Age (years) | 1.00 (0.96- 1.03) |
0.98 (0.95- 1.02) |
1.02 (0.98- 1.07) |
1.03 (0.98- 1.08) |
1.01 (0.98- 1.04) |
1.00 (0.98- 1.03) |
1.03 (0.99- 1.08) |
1.03 (0.99- 1.07) |
| (p=0.96) | (p=0.38) | (p=0.36) | (p=0.27) | (p=0.63) | (p=0.77) | (p=0.12) | (p=0.77) | |
| Hydronephrosis | ||||||||
| No (69, 62, 48) | 1 | 1 | 1 | 1 | ||||
| Yes (13, 29, 40) |
3.72 (1.75-
7.87) (p<0.001) |
4.21 (1.74-
10.15) (p=0.0014) |
1.84(0.91- 3.69) (p=0.09) |
1.71 (0.78- 3.78) (p=0.18) |
2.37 (1.43-
3.94) (p<0.001) |
2.29 (1.33-
3.94) (p=0.003) |
3.20 (1.73-
5.90) (p<0.001) |
3.37 (1.79-
6.36) (p<0.001) |
| Grade | ||||||||
| <G3 (13, 10, 8) | 1 | 1 | 1 | 1 | ||||
| G3 (73, 79, 80) | 1.00 (0.41- 2.41) (p=1.00) |
1.26 (0.51- 3.11) (p=0.62) |
1.20 (0.37- 3.94) (p=0.76) |
1.15 (0.35- 3.85) (p=0.82) |
1.05 (0.52- 2.13) (p=0.88) |
1.10 (0.55- 2.24) (p=0.78) |
2.79 (0.68- 11.50) (p=0.16) |
2.68 (0.63- 11.40) (p=0.18) |
| Tumour -stage | ||||||||
| 1+2 (44, 50, 46) | 1 | 1 | 1 | 1 | ||||
| 3+4 (42, 39, 41) | 1.32 (0.68- 2.58) (p=0.42) |
1.26 (0.62- 2.52) (p=0.52) |
2.08 (1.05-
4.12) (p=0.037) |
1.96 (0.94- 4.08) (p=0.073) |
1.66 (1.03-
2.68) (p=0.038) |
1.60 (0.96- 2.65) (p=0.069) |
1.96 (1.07-
3.56) (p=0.028) |
1.63 (0.89- 3.00) (p=0.11) |
| MRE11 | ||||||||
| Low (21, 23, 22) | 1 | 1 | 1 | 1 | ||||
| High (65, 70, 66) |
0.46 (0.22-
0.97) (p=0.042) |
0.50 (0.23- 1.08) (p=0.076) |
0.46 (0.22-
0.96) (p=0.037) |
0.36 (0.17-
0.78) (p=0.010) |
0.47 (0.28-
0.78) (p=0.004) |
0.39 (0.23-
0.66) (p<0.001) |
1.45 (0.70- 3.02) (p=0.32) |
1.50 (0.70- 3.20) (p=0.29) |
|
Functional TP53
mutation |
||||||||
| 0 (57, 55) | 1 | 1 | 1 | |||||
| 1 (30, 18) | 1.36 (0.70- 2.63) (p=0.37) |
0.66 (0.27- 1.63) (p=0.37) |
1.04 (0.62- 1.74) (p=0.89) |
|||||