Table 2.
The sensitivity of CDC25B-Abs, CEA, CYFRA21-1 and SCC-Ag in detection ESCC.
| Tumor Markers | Total n |
Positive | Negative | |
|---|---|---|---|---|
| n (%) | n (%) | P | ||
| CDC25B-Abs | 134 | 76 (56.7) | 58 (43.3) | |
| SCC-Ag | 134 | 23 (17.2) | 111 (82.8) | |
| CEA | 134 | 18 (13.4) | 116 (86.6) | |
| CYFRA 21-1 | 134 | 43 (32.1) | 91 (67.9) | |
| CEA, SCC-Ag | 134 | 55 (41.0) | 79 (59.0) | |
| or CYFRA21-1 | ||||
| CEA, SCC-Ag, | 134 | 86 (64.2) | 48 (35.8) | <0.001* |
| CYFRA21-1 or CDC25B-Abs | ||||
Abs: antibodies; CEA: carcinoembryonic antigen; SCC-Ag: squamous cell carcinoma antigen; CYFRA21-1: cytokeratin 19 fragment antigen 21-1.
*compared with either CEA, SCC-Ag or CYFRA21-1. Cut-off values: 5.0 ng/ml for CEA; 1.5 ng/ml for SCC-Ag; 3.5 ng/ml for CYFRA21-1