Table 4.

Blood pressure reduction in SERVE^* and the randomized controlled trial COACH⁴

	Δ Systolic BP				Δ Diastolic BP
	SERVE	Pvalue versus baseline	SERVE subgroup**	COACH	SERVE	Pvalue versus baseline	SERVE subgroup**	COACH
BP at baseline	161.8 ± 16.6		166.3 ± 15.4	163.8 ± 16.1	93.6 ± 10.2		108.0 ± 5.9	101.6 ± 5.2
Olmesartan-amlodipine 20/5 mg	−27.6 ± 16.3 (n = 3254)	<0.0001	−31.9 ± 15.4 (n = 989)	−23.6 ± 14.9 (n = 160)	−13.2 ± 10.6 (n = 3254)	<0.0001	−19.5 ± 8.1 (n = 989)	−14.0 ± 9.1 (n = 160)
Olmesartan-amlodipine 40/5 mg	−29.5 ± 16.5 (n = 2749)	<0.0001	−33.0 ± 15.2 (n = 766)	−25.4 ± 14.7 (n = 157)	−13.5 ± 10.5 (n = 2749)	<0.0001	−18.8 ± 8.1 (n = 766)	−15.5 ± 8.2 (n = 157)
Olmesartan-amlodipine 40/10 mg	−31.0 ± 18.8 (n = 2083)	<0.0001	−35.0 ± 18.0 (n = 467)	−30.1 ± 15.9 (n = 161)	−14.1 ± 11.7 (n = 2083)	<0.0001	−19.8 ± 9.7 (n = 467)	−19.0 ± 8.9 (n = 161)

Note:

^*Assignment to dose was based on the previous visit.

^**SERVE patients complying with the COACH in- and exclusion criteria.

Abbreviation: BP, blood pressure.