Table 7.

Comparison of inclusion and exclusion criteria for the SERVE and COACH studies⁴,⁸

	COACH (Randomized, controlled trial)	SERVE (Noninterventional study)
Inclusion	Men or women ≥ 18 years Seated DBP ≥ 95 mmHg and ≤120 mmHg; difference ≤10 mmHg between 2 measurements	Men or women ≥ 18 years Essential hypertension uncontrolled
Exclusion	DBP > 120 mmHg
	History of cardiovascular disease	Cardiogenic shock, acute MI (<4 weeks), unstable angina
	Uncontrolled diabetes	Severely reduced liver function and biliary duct obstruction
	Smoking > one pack of cigarettes
	Laboratory values or systemic disease considered clinicallysignificant by the investigator
	Taking any medication that could interfere with the objectives of the study
	Pregnancy and nursing	2nd and 3rd trimester of pregnancy

Abbreviations: DBP, diastolic blood pressure; MI, myocardial infarction; COACH.