TABLE II.

Pairwise Fst estimates between cohorts in the three study populations from 1993 to 2008. Underlined estimates* reflect pairwise conventional-SPF, conventional-super-SPF and SPF-super-SPF differentiation over time (* only estimates of samples sizes greater than N = 40 are shown in this table). Bold and italicized fonts are estimates of divergence between the Indian super-SPF animals and the conventional and SPF animals while bold and underlined fonts are estimates of divergence between the Chinese super-SPF animals and the conventional and SPF animals. Italicized estimates in shaded boxes are pairwise differentiation between the pure Chinese and Indian-derived super-SPF subpopulations at the CNPRC from 2003 to 2008 (Data from 7211 of the 7536 study animals are presented below. No data were available for the Chinese portion of the super-SPF population in 2002).

Year of Birth	1993	1997	2001	2005	2008	2001 SPF	2005 SPF	2008 SPF	2005 super-SPF	2006 super-SPF	2007 super-SPF	2008 super-SPF
1997	0.0017
2001	0.0049	0.0018
2005	0.0138	0.0118	0.0098						0.0009 0.0627
2008	0.0112	0.0094	0.0082	0.0007								0.0072 0.0673
2001 SPF	0.0061	0.0028	0.001	0.0121	0.0098
2005 SPF	0.009	0.0059	0.0061	0.0042	0.0038	0.0056			0.0106 0.0646
2008 SPF	0.0156	0.0114	0.0087	0.0052	0.0055	0.0074	0.0006					0.0059 0.0858
2005 super- SPF	0.0101	0.0135	0.0159	0.0041	0.0056	0.0185	0.0099	0.0135	0.0814
2006 super- SPF	0.013	0.0164	0.019	0.0069	0.0058	0.0211	0.0094	0.0149	0.0014	0.0793
2007 super- SPF	0.0116	0.0125	0.0135	0.0025	0.0028	0.0152	0.0061	0.0092	0.002	0.0035	0.0792
2008 super- SPF	0.0138	0.0136	0.0143	0.0037	0.004	0.0158	0.0044	0.007	0.0016	0.0048	0.003	0.0959