Table 3.
CP metabolite ions identified in the LC-MS-based metabolomic analysis of urine samples from CP-treated mice
| Symbol | Rt (min) | m/z ( ESI+) | Formula | Mass Error (ppm) | Identity | Peak area (Mean ± SD) |
|---|---|---|---|---|---|---|
| P1 | 4.53 | 261.0333 | C7H15Cl2N2O2P | 2.7 | Cyclophosphamide | 1047.2 ± 311.5 |
| P2 | 3.57 | 293.0227 | C7H15Cl2N2O4P | 0.7 | Carboxyphosphamide | 2105.4 ± 416.9 |
| P3 | 2.42 | 199.0405 | C5H12ClN2O2P | 1.0 | Dechloroethylcyclophosphamide | 333.6 ± 68.3 |
| P4 | 3.81 | 277.0267 | C7H15Cl2N2O3P | −3.2 | Aldophosphamide | 7.6 ± 3.2 |
| P5 | 3.73 | 279.0437 | C7H17Cl2N2O3P | 1.8 | Alcophosphamide | 251.8 ± 27.8 |
| P6 | 3.20 | 259.0171 | C7H13Cl2N2O2P | 0.4 | Iminocyclophosphamide | 31.8 ± 7.7 |
| P7 | 3.32 | 221.0019 | C4H11Cl2N2O2P | 2.7 | Phosphamide mustard | 7.6 ± 4.4 |
| P8 | 3.01 | 277.0279 | C7H15Cl2N2O3P | 1.1 | 4-Hydroxycyclophosphamide | 7.6 ± 2.4 |
| P9 | 3.19 | 455.0781 | C13H25Cl2N2O9P | 2.6 | Alcophosphamide glucuronide | 5.8 ± 1.5 |
| P10 | 3.58 | 275.0100 | C7H13Cl2N2O3P | −6.9 | 4-Ketocyclophosphamide | 455.8 ± 69.3 |
| P11 | 1.83 | 213.0198 | C5H10ClN2O3P | 0.9 | Dechloroethylketocyclophosphamide | 117.2 ± 24.3 |
| P12 | 1.86 | 217.0511 | C5H14ClN2O3P | 0.9 | Dechloroethylalcophosphamide | 23.2 ± 3.8 |