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Major metabolic reactions and corresponding metabolites in mouse urine following treatment with IF and CP
| Metabolic reaction | IF | CP |
|---|---|---|
| Unchanged drug | F1 | P1 |
| Dechloroethylation | F2, F3 | P2, P11, P12 |
| Hydroxylation | F11 | P8 |
| Ketonization | F7 | P10 |
| Desaturation | F5 | P6 |
| β-Elimination of acrolein | F9 | P7 |
| Ring-opening | F4, F6, F8 | P2, P4, P5 |
| Glucuronic acid conjugation | F11 | P9 |
