Table 2.
Bleeding and treatment parameters of patients with severe haemophilia A in the on-demand group (OD) and in the continuous prophylaxis group (CP) in the observation period of 1 year
| OD (n = 26) | CP (n = 26) | p value | |
|---|---|---|---|
| FVIII consumption per year, IU | 1,543,000 | 5,229,250 | |
| Number of infusions/bleed | 1.5 ± 0.2 | 1.8 ± 0.2 | 0.2695 |
| Treatment delay after recognition of the bleed, h | 2.6 ± 0.8 | 1.6 ± 0.7 | 0.4282 |
| Mean weekly FVIII injection rate/patient | 0.56 ± 0.08 | 2.52 ± 0.30 | 0.0001 |
| Bleeding classification | |||
| Number of patients with no bleeds/month) (%) | 0 (0%) | 3 (12%) | |
| Number of patients with 1–2 bleeds/month (%) | 16 (62%) | 23 (88%) | |
| Number of patients with >2 bleeds/month (%) | 10 (38%) | 0 (0%) | |
| Days with FVIII infusion per patient and year | |||
| Total number of days | 29.3 ± 4.1 | 131.2 ± 16.9 | 0.0001 |
| Number of days to treat acute bleeds | 28.4 ± 4.0 | 13.3 ± 2.3 | 0.0022 |
| Number of days with prophylactic treatment | 0.9 ± 0.4 | 117.9 ± 15.7 | 0.0001 |