Fig. 2.

Development of vascular architecture, as revealed with IB4, in the cortex (A-D) and rostral forebrain region (E-O) at different ages from E14 to P4. The vasculature of the rostral forebrain region has no or little apparent organization at E14 and E16. However, blood vessels appear to align in the direction of the RMS at P2 and P4, suggesting extensive remodelling late in development. A, B, E, F Scale bar = 200 μm. C, D, G, H Scale bar = 500 μm. M Schematic drawing of a mouse brain in a sagittal plane. The blue box represents the brain area shown in A-D and the green box represents that in E, F. Insets in G and H are shown at higher magnification in N and O. The RMS as it runs rostral to reach olfactory bulb is outlined in G, H, N and O. CTX = Cortex; LV = lateral ventricle; OB = olfactory bulb.