TABLE 2.
Scores on Study Measures in 17 Subjects with Body Dysmorphic Disorder Treated with Levetiracetam
| Measure | Baselinea,b | Endpointa,b | Statistic | df | Significance | |
|---|---|---|---|---|---|---|
| BDD-YBOCS | 32.5 ± 4.7 | 21.5 ± 11.0 | F=12.27 | 2.71, 43.28 | <.001 | |
| CGI (Clinician) - % Much or Very Much Improved | ||||||
| BDD | 47.1% (n=8) | |||||
| Global | 52.9% (n=9) | |||||
| CGI (Patient) - % Much or Very Much Improved | ||||||
| BDD | 47.1% (n=8) | |||||
| Global | 47.1% (n=8) | |||||
| Clinical Global Severity c | 5.2 ± 1.0 | 4.2 ± 1.6 | F = 6.08 | 3.68, 8.87 | .001 | |
| Brown Assessment of Beliefs Scale d | 14.6 ± 4.3 | 10.4 ± 5.3 | t = 3.47 | 15 | .003 | |
| Hamilton Depression Rating Scale (24 item) | 18.1 ± 6.4 | 11.4 ± 8.4 | F= 4.22 | 2.81, 44.97 | .012 | |
| Beck Anxiety Inventory | 12.4 ± 6.8 | 9.6 ± 5.5 | t = 1.50 | 16 | .154 | |
| Social Phobia Inventory | 32.9 ± 12.4 | 29.4 ± 13.8 | t = 1.37 | 16 | .189 | |
| Global Assessment of Functioning (GAF) Scale | 46.1 ± 7.8 | 55.8 ± 14.5 | t = −3.33 | 16 | .004 | |
| Social and Occupational Functioning Assessment | 47.0 ± 8.5 | 59.8 ± 18.6 | t = −3.33 | 16 | .004 | |
| Scale | ||||||
| Q-LES-QShort Form e | 49.5 ± 10.3 | 57.4 ± 14.8 | t = −1.82 | 16 | .087 | |
Abbreviations: BDD-YBOCS, Yale–Brown Obsessive Compulsive Scale Modified for Body Dysmorphic Disorder; CGI, Clinical Global Improvement; Q-LES-Q, Quality of Life Satisfaction and Enjoyment Questionnaire.
Data are presented as mean ± standard deviation, or % (n); all data presented are intention-to-treat with the last observation carried forward.
Higher scores indicate greater symptom severity on the BDD-YBOCS, Brown Assessment of Beliefs Scale, Hamilton Depression Rating Scale, Beck Anxiety Inventory, and Social Phobia Inventory. Lower scores indicate poorer functioning/quality of life on the Global Assessment of Functioning Scale, Social and Occupational Functioning Assessment Scale, and Q-LES-Q.
The mean Clinical Global Severity score for BDD at baseline was in the markedly ill (score of 5) to severely ill (score of 6) range. The endpoint score was in the moderately ill (score of 4) to markedly ill (score of 5) range.
The mean Brown Assessment of Beliefs Scale score is in the poor insight range at baseline and the fair insight range at endpoint.
Converted (transformed) scores for the Q-LES-Q Short Form are reported.