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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Dis Mon. 2010 Sep;56(9):484–546. doi: 10.1016/j.disamonth.2010.06.001

Table 4.

Summary of Braak Staging.

Anatomical Stage Braak
Stage		 Medial Temporal Tau
Pathology		 Isocortical Tau
Pathology
Transentorhinal* I–II Limited to transentorhinal
and entorhinal involvement		 Minimal
Limbic III–IV Transentorhinal, entorhinal,
Ammon’s horn involvement		 Moderate
Isocortical V–VI Extensive medial temporal
involvement		 Advanced
*

Note that in the original Braak study, none of the patients in the transentorhinal stage were clinically demented during life. About half of the subjects in the limbic stage were demented, and all in the isocortical stage were demented.