A) Contralateral eyes were injected with either 250 μM BzATP or 250 μM BzATP + 10 μM A3 receptor agonist MRS3558. Co-injection of MRS3558 significantly increased the number of surviving ganglion cells in the nasal and superior quadrants (* p<0.001, paired t-test, n=48 corresponding regions from 8 adolescent rats).
B) Representative image from peripheral nasal region of eye injected with BzATP.
C) Corresponding region from contralateral eye injected with BzATP + MRS3558. In panels C and D, bar = 50 μm.