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. Author manuscript; available in PMC: 2011 Aug 26.
Published in final edited form as: Neuron. 2010 Aug 26;67(4):575–587. doi: 10.1016/j.neuron.2010.07.019

Fig. 7. Effects of misfolded SOD1 binding to VDAC1.

Fig. 7

Schematic model showing the effects of misfolded SOD1 binding to VDAC1. Misfolded SOD1 is proposed to inhibit VDAC1 conductance and suppress both uptake and release of mitochondrial metabolites. This reduction in metabolites flux would result in reduced energy production and oxidative stress leading to mitochondrial dysfunction.