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Reporter gene assays of wild type AR and T877A AR mutant activity. Representative compounds show dose-dependent inhibition of full-length androgen receptor (a) or T877A full-length androgen receptor mutant (c) action. Compounds were also assayed against wild type AR (b) or T877A AR (d) activated with both 1 nM and 100 nM DHT to show the independence of CBI action from ligand concentration.
