Table 1.
Numbers of Genes Corresponding to Core Carbon Metabolic Pathways and Other Representative Pathways in Five Diverse Microsporidian Genomes
| Biochemical Pathways | Encephalitozoon cuniculi | Antonospora locustae | Octosporea bayeri | Nosema ceranae | Enterocytozoon bieneusi | |
| Genomic data available | Sanger (complete) | Sanger | Solexa | 454 | Sanger | 454 |
| Estimated genome size (Mb) | 2.9 | 5.6 | ≤24.2 | ≤10 | 6 | |
| (A) Pathways with strong differences among species | ||||||
| Glycolysis | 12 | 12 | 12 | 12 | 1 | 1 |
| Pentose phosphate pathway | 5 | 5 | 5 | 5 | 1 | 1 |
| Trehalose metabolism | 4 | 4 | 4 | 4 | 0 | 0 |
| Fatty acids biosynthesis | 20 | 19 | 20 | 19 | 5 | 6 |
| Number of ORFs | 41 | 40 | 41 | 40 | 7 | 8 |
| (B) Pathways present in all species | ||||||
| Transcriptional control | 44 | 41 | 44 | 34 | 39 | 39 |
| 60S ribosomal proteins | 46 | 39 | 39 | 39 | 45 | 43 |
| 40S ribosomal proteins | 31 | 31 | 29 | 25 | 26 | 27 |
| tRNA synthetases | 21 | 21 | 21 | 21 | 21 | 21 |
| rRNA processing | 20 | 20 | 18 | 19 | 18 | 18 |
| Recombination and DNA repair | 22 | 20 | 21 | 20 | 19 | 19 |
| Meiosis | 18 | 18 | 15 | 18 | 14 | 13 |
| Protein kinases | 19 | 18 | 14 | 17 | 18 | 19 |
| Transcription initiation factors | 18 | 18 | 18 | 15 | 17 | 17 |
| Cell growth and cell polarity | 11 | 8 | 9 | 10 | 10 | 9 |
| Deoxyribonucleotide metabolism | 11 | 6 | 7 | 4 | 11 | 10 |
| C-compound and carbohydrate metabolism | 9 | 9 | 9 | 8 | 7 | 7 |
| DNA-directed DNA polymerases | 8 | 8 | 8 | 8 | 8 | 8 |
| DNA replication factors A and C | 8 | 7 | 6 | 5 | 8 | 8 |
| DNA replication licensing factors, MCM family | 8 | 8 | 8 | 8 | 8 | 8 |
| tRNA modification | 7 | 7 | 7 | 6 | 7 | 7 |
| tRNA synthesis | 7 | 7 | 7 | 6 | 6 | 6 |
| DNA-dependent helicases, ligases, telomerases | 7 | 7 | 7 | 7 | 7 | 7 |
| Chromosome segregation proteins, SMC family | 5 | 5 | 5 | 5 | 5 | 5 |
| Phosphate metabolism | 5 | 3 | 5 | 5 | 5 | 5 |
| Amino acid metabolism | 4 | 4 | 3 | 4 | 3 | 3 |
| Transcription elongation factors | 3 | 3 | 2 | 3 | 3 | 3 |
| DNA topoisomerases | 3 | 3 | 3 | 2 | 3 | 3 |
| Nitrogen and sulfur metabolism | 3 | 3 | 3 | 2 | 2 | 2 |
| Polynucleotide degradation | 2 | 2 | 2 | 2 | 2 | 2 |
| tRNA processing | 2 | 2 | 2 | 1 | 2 | 2 |
| Origin recognition complex | 2 | 2 | 2 | 1 | 2 | 2 |
| Glycerol phosphate shuttle | 2 | 2 | 2 | 2 | 1 | 1 |
| Sugar transporters | 3 | 2 | 2 | 3 | 3 | 3 |
| ADP/ATP transporters | 4 | 3 | 1 | 4 | 4 | 4 |
| Number of ORFs | 353 | 327 | 319 | 304 | 324 | 321 |
| Total ORFs | 394 | 367 | 360 | 344 | 331 | 329 |
MCM, minichromosome maintenance; ORF, open reading frame; rRNA, ribosomal RNA; SMC, structural maintenance of chromosomes; tRNA, transfer RNA.