Figure 1 Neuropathologic lesions and global cognitive decline

Predicted path of global cognitive decline at high (75th percentile, red line) and low (25th percentile, green line) levels of neurofibrillary tangles (A); with chronic gross (B) and microscopic (C) infarction present (red line) or absent (green line); with Lewy bodies present (neocortical, red line; nigral/limbic, blue line) or absent (green line) (D).