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. 2010 Aug 19;7:34. doi: 10.1186/1742-4682-7-34

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Copyright ©2010 Best et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Homeostatic effects of the autoreceptors. Panel A shows hows extracellular 5-HT (e5ht) changes as the firing rate of the neuron varies above and below normal both with and without the autoreceptors. Panel B shows how extracellular 5-HT changes with the expression level of the SERTs both with and without the autoreceptors. s/s and l/l indicate the activities of the corresponding genotypes. Panel C shows how extracellular 5-HT changes with the activity level of TPH both with and without the autoreceptors. The activities of the R441 H and P449R polymorphims are indicated. In all cases, the autoreceptors reduce the effect of changes in firing rate and polymorphisms on extracellular 5-HT.