Table 4.
Steady State Values from WT to SERT KO
| f * = 1(WT) | f = .5 | f = .2 | f = .1 | f = .05 | f = 0(SERT KO) | |
|---|---|---|---|---|---|---|
| trp | 20.1 | 20.9 | 21.1 | 21.1 | 21.2 | 21.3 |
| c5 - HT | 0.5 | 0.39 | 0.3 | 0.25 | 0.19 | 0.05 |
| v5 - HT | 21.5 | 19.9 | 18.1 | 17.05 | 14.67 | 6.41 |
| e5 - HT ** | .7 | 1.18 | 1.82 | 2.26 | 3.32 | 6.2 |
| 5 - hiaa | 5.3 | 4.12 | 3.13 | 2.7 | 1.99 | 0.63 |
| VTPH | 5.57 | 4.59 | 3.86 | 3.6 | 3.32 | 3.12 |
| VMAT | 21.4 | 16.7 | 10.7 | 7.09 | 5.87 | 2.56 |
| VSERT | 21.1 | 16.2 | 9.93 | 6.16 | 4.5 | 0.0 |
| Vrem | 0.31 | 0.47 | 0.73 | 0.9 | 1.33 | 2.50 |
| Vcatab | 5.26 | 4.12 | 3.13 | 2.7 | 1.99 | 0.63 |
* f is the fraction of SERTs that are functional.
** concentration in nM, all other concentrations in μM. Velocities have units μM/hr.