Figure 3.

Sequence conservation between the N-terminal halves of fungal and non-fungal eukaryotic tRNase Z^Ls. Multiple sequence alignment of the N-terminal halves of representative fungal and non-fungal eukaryotic tRNase Z^Ls according to the same legend as in Figure 2. The positions of amino acid residues of the D. melanogaster tRNase Z^L that contribute to substrate binding are marked with an asterisk [44]. Open circle denotes the residue in the D. Melanogaster tRNase Z^L that makes the largest contribution to substrate binding [44].