Figure 12.

Schematic illustrations summarizing the present findings. (A) Comparison between the previous model and the present findings of the behavior of nascent Purkinje cells to initiate the PP. Sagittally sectioned cerebella are illustrated and radial fibers (RF) indicated. The pial side is top and posterior is right. (B) Illustration showing the differential behaviors of posteriorly E10.5-born Purkinje cells in normal and reeler cerebella from E13.5 to E14.5. The most important difference is whether they change their posture/orientation from horizontal or axon-top to axon-bottom (normal) or not (reeler). The initial migration (mostly tangential) and axonogenesis (anteriorly) are normal in reeler cerebella until E13.5, although Purkinje cells in E13.5 reeler cerebella might have slight morphological abnormalities concerning the elaboration of non-axon (dendrite-like) processes on the posterior/ventricular pole of the soma (indicated by question marks).