Table 1.
Markers of Vascular Dysfunction and HIV RNA by Quartile of IL-6, D-dimer, and Joint (IL-6 / D-dimer) Risk Score
| Quartile of IL-6 | Comparison of Quartiles (4th vs. 1st) |
Spearman’s Rank Correlation |
||||||
|---|---|---|---|---|---|---|---|---|
| Surrogate Marker | 1st | 2nd | 3rd | 4th | Percent (%) Difference* |
p-value | R | p-value |
| LAE (mmHg/mL × 10) | 16.5 | 15.7 | 18.2 | 15.1 | −9.90 | 0.50 | −0.14 | 0.45 |
| SAE (mmHg/mL × 100) | 8.2 | 6.3 | 6.7 | 5.6 | −37.8 | 0.03 | −0.33 | 0.06 |
| sICAM-1 (ng/mL) | 252 | 397 | 424 | 554 | 77.1 | 0.07 | 0.34 | 0.05 |
| E-selectin (ng/mL) | 32.0 | 33.6 | 60.8 | 65.7 | 86.4 | 0.02 | 0.57 | 0.001 |
| HIV-RNA (log10 copies/mL) | 4.0 | 4.1 | 4.1 | 4.4 | 11.3 | 0.08 | 0.26 | 0.15 |
| Quartile of D-dimer Level | ||||||||
| 1st | 2nd | 3rd | 4th | |||||
| LAE (mmHg/mL × 10) | 15.6 | 16.1 | 17.6 | 16.2 | 2.1 | 0.90 | 0.18 | 0.34 |
| SAE (mmHg/mL × 100) | 8.0 | 6.7 | 6.5 | 5.7 | −33.9 | 0.12 | −0.27 | 0.13 |
| sICAM-1 (ng/mL) | 275 | 452 | 277 | 601 | 94.8 | 0.05 | 0.29 | 0.11 |
| E-selectin (ng/mL) | 27.9 | 49.6 | 41.3 | 70.7 | 138.2 | 0.001 | 0.54 | 0.001 |
| HIV-RNA (log10 copies/mL) | 4.1 | 4.5 | 3.5 | 4.4 | 5.9 | 0.48 | 0.06 | 0.73 |
|
Quartile of Joint (IL-6 / D-dimer) Mortality Risk Score |
||||||||
| 1st | 2nd | 3rd | 4th | |||||
| LAE (mmHg/mL × 10) | 15.6 | 17.6 | 16.9 | 15.5 | −2.1 | 0.89 | −0.06 | 0.74 |
| SAE (mmHg/mL × 100) | 8.5 | 7.1 | 5.6 | 5.5 | −41.5 | 0.02 | −0.42 | 0.02 |
| sICAM-1 (ng/mL) | 256 | 391 | 352 | 628 | 114.5 | 0.01 | 0.41 | 0.02 |
| E-selectin (ng/mL) | 30.0 | 39.4 | 50.0 | 72.7 | 130.5 | 0.001 | 0.67 | <0.001 |
| HIV-RNA (log10 copies/mL) | 4.0 | 4.1 | 4.1 | 4.3 | 7.1 | 0.33 | 0.25 | 0.17 |
*
Percent differences were obtained by exponentiating the loge transformed means.