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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem Biol. 2010 Aug 22;6(10):774–781. doi: 10.1038/nchembio.424

Figure 4. Mutational spectra in pol2-M644G rnh201Δ strains.

Figure 4

The coding strand of the 804 base pair URA3 open reading frame is shown. The sequence changes observed in independent ura3 mutants are depicted in red above the coding sequence for URA3 orientation 1, and in blue below the coding sequence for URA3 orientation 2. Letters indicate single base substitutions, closed triangles indicate single base additions, open triangles indicate single base deletions, and short lines above or below the coding sequence indicate 2–5 base deletions. Solid boxes enclose perfect direct repeat sequences, and dashed boxes enclose imperfect direct repeat sequences. The solid green box highlights a CACA repeat at which no deletions were observed.