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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Eur J Neurosci. 2010 Aug 19;32(6):963–973. doi: 10.1111/j.1460-9568.2010.07335.x

Fig. 6. Mechanisms of inhibition of substance P release from primary afferent terminals.

Fig. 6

Substance P (SP) and glutamate (Glu) are released when Ca2+ enters the terminal through Ca(V) channels. MORs, GABAB receptors (GABABRs) and α2A receptors inactivate (-) Ca(V)2.2 through Gβ γ. MORs and GABABRs also inactivate Ca(V)2.2 by Tyr (Y)-phosphorylation by SFKs. NE: norepinephrine; enk: enkephalin.