TABLE 1.
Demographic, Clinical and Laboratory Characteristics
| Test Set (n=30) | Validation Set (n=365) | |||||
|---|---|---|---|---|---|---|
| Control (n=15) | AKI (n=15) | P values | Control (n=230) | AKI (n=135) | P values | |
| Patient Demographics | ||||||
| Age (yr) | 3.9±5.3 | 4.0±7.8 | 0.9 | 3.9±4.5 | 3.6±4.6 | 0.6 |
| Males | 8 (53%) | 9 (60%) | 0.7 | 123(53%) | 72 (53%) | 0.9 |
| Caucasians | 13 (87%) | 13 (87%) | 0.9 | 191 (83%) | 117 (87%) | 0.4 |
| Previous surgery | 4 (27%) | 5 (33%) | 0.7 | 76 (33%) | 61 (45%) | 0.03 |
| Bypass Time (min) | 80.5±29.3 | 153.9±61.9 | <0.001 | 100.6±46 | 143.7±63.2 | <0.001 |
| Clinical Variables | ||||||
| Pre-op SCr | 0.47±0.2 | 0.42±0.2 | 0.5 | 0.5±0.2 | 0.4±0.2 | <0.001 |
| ΔSCr at 24 hr (%) | −3±20 | −7±25 | 0.3 | −4±18 | 25±35 | <0.001 |
| ΔSCr at 48 hr (%) | −11±23 | 83±49 | 0.002 | 2.3±20 | 68±59 | <0.001 |
| ΔSCr at 72 hr (%) | −11±46 | 79±44 | 0.001 | −1.5±20 | 91±74 | <0.001 |
| Inotrope Score | 3.9±3.6 | 9.0±6.2 | <0.001 | 2.0±4.6 | 5.9±7.3 | <0.001 |
| Hospital Stay (days) | 5.2±2.2 | 22.3±16.9 | <0.001 | 5.6 ± 4.3 | 13.1±15 | <0.001 |
| Dialysis | 0 (0%) | 1 (6.7%) | 0.3 | 0 (0%) | 7 (5%) | <0.001 |
| Death | 0 (0%) | 2 (13%) | 0.2 | 0 (0%) | 6 (4%) | 0.002 |
| Days in AKI | 0 | 3.1±2.3 | N/A | 0 | 3.6±3.7 | N/A |
| Laboratory Measures | ||||||
| Peak* A1M 0 hr | 0.47±0.26 | 0.46±0.2 | 0.9 | ND | ND | |
| Peak* A1M 2 hr | 0.54±0.27 | 3.93±1.4 | <0.001 | ND | ND | |
| A1M mg/dl 0 hr | 1.04±0.57 | 1.09±0.71 | 0.8 | 0.9±1.5 | 0.8±1.3 | 0.8 |
| A1M mg/dl 2 hr | 1.98±0.95 | 8.04±4.79 | <0.001 | 2.4±2.5 | 8.4±6.3 | <0.001 |
| Peak* AAG 0 hr | 0.29±0.07 | 0.30±0.1 | 0.8 | ND | ND | |
| Peak* AAG 2 hr | 0.32±0.08 | 2.48±1.3 | <0.001 | ND | ND | |
| AAG mg/dl 0 hr | 0.55±0.80 | 0.68±0.75 | 0.7 | 0.6±1.5 | 0.6±1.6 | 0.9 |
| AAG mg/dl 2 hr | 0.80±1.0 | 8.1±5.4 | <0.001 | 1±2 | 7.5±7.0 | <0.001 |
| Peak* Alb 0 hr | 1.67±0.98 | 1.87±0.74 | 0.5 | ND | ND | |
| Peak* Alb 2 hr | 2.27±1.49 | 34.73±11.7 | <0.001 | ND | ND | |
| Alb mg/dl 0 hr | 2.65±2.6 | 2.89±2.6 | 0.8 | 2.9±4.3 | 2.6±2.9 | 0.4 |
| Alb mg/dl 2 hr | 8.63±7.5 | 27.1±18.9 | <0.001 | 9.8±12.8 | 24.4±28.2 | <0.001 |
Values are means±SEM. P values are for comparisons between control and AKI groups.
AKI, acute kidney injury (defined as ≥50% increase in SCr from baseline values); SCr, serum creatinine; A1M, α1-microglobulin; AAG, α1-acid glycoprotein; Alb, albumin; N/A, not applicable; pre-op, pre-operative; ND, not done.
*
Refers to peak intensity