Figure 1.

Illustration of phenotypes from 20 consomic strains. a) The tumor incidence at week 15 after carcinogen treatment was calculated to 29% (4/14) and 54% (7/13) in the SS-3^BN and SS-5^BN consomic rat, respectively, which is significantly reduced compared with the SS parental strain (93%; 37/40) (SS vs. SS-3^BN, P<0.0001; SS vs. SS-5^BN, P=0.0317). b) Comparison of tumor latency showed a significantly different value for the SS-3^BN (black line, filled circles in the figure), d), SS-9^BN (black dashed line, open diamonds), SS-14^BN (green dotted line, open stars) and SS-19^BN consomic strains (purple dotted line, open triangles) vs. the SS (blue dotted line, stars) (SS vs. SS-3^BN, P=0.0043; SS vs. SS-9^BN, P=0.0018; SS vs. SS-14^BN, P<0.0001; SS vs. SS-19^BN, P<0.0001). c) A significant difference in tumor multiplicity was observed in the SS-13^BN, SS-16^BN and SS-19^BN rat compared to the SS (SS vs. SS-13^BN, P=0.0024; SS vs. SS-16^BN, P=0.0002; SS vs. SS-19^BN, P<0.0001; standard deviation (s.d.) is given). Due to a high death incidence (+) of the SS-6^BN consomic females early after carcinogen treatment, a true value of tumor incidence and multiplicity was not possible to obtain.