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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Genes Chromosomes Cancer. 2010 Nov;49(11):1035–1045. doi: 10.1002/gcc.20812

Figure 3.

Figure 3

Illustration of phenotypes from congenic lines derived from the SS-6BN consomic rat. a) Comparison of tumor latency showed a significantly different value for the SS.BN-(D6Rat119-D6RatArb3) strain compared to the SS (SS vs. SS.BN-(D6Rat119-D6RatArb3), P<0.0001). SS: black line, filled circles; SS.BN-(D6Rat149-D6Rat18): purple dotted line, open triangles; SS-6BN: dashed black line, open diamonds; SS.BN-(D6Rat149-D6RatHF8): red dotted line, open circles; SS.BN-(D6Rat149-D6Arb3): green dotted line, open stars; SS.BN-(D6Rat119-D6Arb3): blue dotted line, stars. b) Also a significant difference in tumor multiplicity was observed in the SS.BN-(D6Rat119-D6RatArb3) rat compared to the SS (SS vs. SS.BN-(D6Rat119-D6RatArb3), P=0.0003; s.d. is given). c) The death rates were evaluated to 57% (8/14) for the SS.BN-(D6Rat149-D6RatArb3), 80% (12/15) for the SS.BN-(D6Rat149-D6Rat18) and 40% (6/15) for the SS.BN-(D6Rat149-D6RatHF8) congenic by the end of week 15, all of which showed a significant phenotypic difference compared with the SS (SS vs. SS.BN-(D6Rat149-D6RatArb3), P<0.0001; SS vs. SS.BN-(D6Rat149-D6Rat18), P<0.0001; SS vs. SS.BN-(D6Rat149-D6RatHF8), P=0.0044). Due to a high death incidence (+) of the SS.BN-(D6Rat149-D6RatArb3), SS.BN-(D6Rat149-D6Rat18) and SS.BN-(D6Rat149-D6RatHF8) females (similarly to what was observed in the SS-6BN consomic females), a true value of the tumor phenotypes were not possible to obtain. SS: black line, filled circles; SS.BN-(D6Rat149-D6Rat18): purple dotted line, open triangles; SS-6BN, black dashed line, open diamonds; SS.BN-(D6Rat149-D6RatHF8): red dotted line, open circles; SS.BN-(D6Rat149-D6RatArb3): green dotted line, open stars; SS.BN-(D6Rat119-D6RatArb3): blue dotted line, stars.