Table 3.
| Test | PBS | simvastatin | Adv | simvastatin + Adv |
|---|---|---|---|---|
| T-maze | ||||
| Alternations (%) | 63±4 | 69±4 | 77±3a | 64±3 |
| Choice latencies/trial (s) | 8±1 | 10±1 | 10±1 | 8±1 |
| Elevated plus-maze | ||||
| Open arm entries | 13±1 | 10±1b | 10±0.7b | 14±1 |
| Enclosed arm entries | 16±1 | 16±2 | 14±1 | 15±1 |
| Open/total entries (%) | 46±2 | 37±4a | 433 | 47±3 |
| Open arm duration (s) | 67±8 | 60±10 | 69±7 | 79±6 |
| Enclosed arm duration (s) | 163±9 | 181±10 | 163±7 | 148±5 |
| Open/total duration (%) | 22±3 | 20±3 | 23±2 | 26±2 |
Effects of vaccine and simvastatin on exploratory activity in C57BL/6J mice. Values are means ± S.E.M.,
a
P < 0.05, and
b
P < 0.01 vs other groups.